研究業績
2023
- Isolation of stage-specific spermatogenic cells by dynamic histone incorporation and removal in spermatogenesis.
Fujiwara Y*, Hada M*, Fukuda Y, Koga C, Inoue E, Okada Y (2023)
Cytometry: Part A (* equal contribution)
- New allele of mouse DNA/RNA helicase senataxin causes meiotic arrest and infertility
Fujiwara Y, Saito K, Sun F, Petri S, Inoue E, Schimenti J, Okada Y, Handel MA (2023)
Reproduction
2022
- Solubilization of Mouse Sperm Chromatin for Sequencing Analyses Using a Chaperon Protein
Fukuda Y, Shintomi K, Yamaguchi K, Fujiwara Y, Okada Y (2022)
Methods in Molecular Biology
- Epigenetic regulator Cfp1 safeguards male meiotic progression by regulating meiotic gene expression.
Ki BS, Shim SH, Park C, Yoo H, La H, Lee OH, Kwon Y, Skalnik DG, Okada Y, Yoon HG, Kim JH, Hong K, Choi Y (2022)
Experimental & Molecular Medicine
- Sperm chromatin condensation: epigenetic mechanisms to compact the genome and spatiotemporal regulation from inside and outside the nucleus.
Okada Y (2022)
Genes & Genetic Systems
- Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function.
Yamamuro T, Nakamura S, Yamano Y, Endo T, Yanagawa K, Tokumura A, Matsumura T, Kobayashi K, Mori H, Enokidani Y, Yoshida G, Imoto H, Kawabata T, Hamasaki M, Kuma A, Kuribayashi S, Takezawa K, Okada Y, Ozawa M, Fukuhara S, Shinohara T, Ikawa M, Yoshimori T (2022)
PLOS Genetics
- R-Loop Formation in Meiosis: Roles in Meiotic Transcription-Associated DNA Damage
Fujiwara Y, Handel MA, Okada Y (2022)
Epigenomes
- Potential role of KRAB-ZFP binding and transcriptional states on DNA methylation of retroelements in human male germ cells.
Fukuda K, Makino Y, Kaneko S, Shimura C, Okada Y, Ichiyanagi K and Shinkai Y (2022)
Elife
- Sperm chromatin structure: insights from in vitro to in situ experiments
Okada Y (2022)
Current Opinion in Cell Biology
2021
- Preparation of optimized concanavalin A-conjugated Dynabeads(R) magnetic beads for CUT&Tag.
Fujiwara Y, Tanno Y, Sugishita H, Kishi Y, Makino Y and Okada Y (2021)
PLOS ONE IQBプレスリリース
- Identification and characterization of the antigen recognized by the germ cell mAb TRA98 using a human comprehensive wet protein array.
Fukuda E, Tanaka H, Yamaguchi K, Takasaka M, Kawamura Y, Okuda H, Isotani A, Ikawa M, Shapiro VS, Tsuchida J, Okada Y, Tsujimura A, Miyagawa Y, Fukuhara S, Kawakami Y, Wada M, Nishimune Y and Goshima N (2021)
Genes to Cells
- Protocol for isolation of spermatids from mouse testes.
Kim CR, Noda T, Okada Y, Ikawa M and Baek SH (2021)
STAR Protocols
2020
- Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase.
Fujiwara Y, Horisawa-Takada Y, Inoue E, Tani N, Shibuya H, Fujimura S, Kariyazono R, Sakata T, Ohta K, Araki K, Okada Y and Ishiguro KI (2020)
PLOS Genetics IQBプレスリリース
- PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis.
Kim CR, Noda T, Kim H, Kim G, Park S, Na Y, Oura S, Shimada K, Bang I, Ahn JY, Kim YR, Oh SK, Choi HJ, Kim JS, Jung I, Lee H, Okada Y, Ikawa M and Baek SH (2020)
Cell Reports
- A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation.
Tsuboyama K, Osaki T, Matsuura-Suzuki E, Kozuka-Hata H, Okada Y, Oyama M, Ikeuchi Y, Iwasaki S and Tomari Y (2020)
PLOS Biology
2019
2018
- Neonatal testis growth recreated in vitro by two-dimensional organ spreading.
Kojima K, Nakamura H, Komeya M, Yamanaka H, Makino Y, Okada Y, Akiyama H, Torikai N, Sato T, Fujii T, Kimura H and Ogawa T (2018)
Biotechnology and Bioengineering
- Re-evaluating the Localization of Sperm-Retained Histones Revealed the Modification-Dependent Accumulation in Specific Genome Regions.
Yamaguchi K, Hada M, Fukuda Y, Inoue E, Makino Y, Katou Y, Shirahige K and Okada Y (2018)
Cell Reports IQBプレスリリース
2017
- TH2A is phosphorylated at meiotic centromere by Haspin.
Hada M, Kim J, Inoue E, Fukuda Y, Tanaka H, Watanabe Y and Okada Y (2017)
Chromosoma
- Use of Histone K-M Mutants for the Analysis of Transcriptional Regulation in Mouse Zygotes.
Aoshima K, Kimura T and Okada Y (2017)
Methods in Molecular Biology
- Identification of a variant-specific phosphorylation of TH2A during spermiogenesis.
Hada M, Masuda K, Yamaguchi K, Shirahige K and Okada Y (2017)
Scientific Reports
- Meikin-associated polo-like kinase specifies Bub1 distribution in meiosis I.
Miyazaki S, Kim J, Yamagishi Y, Ishiguro T, Okada Y, Tanno Y, Sakuno T and Watanabe Y (2017)
Genes to Cells
- Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.
Ueda J, Harada A, Urahama T, Machida S, Maehara K, Hada M, Makino Y, Nogami J, Horikoshi N, Osakabe A, Taguchi H, Tanaka H, Tachiwana H, Yao T, Yamada M, Iwamoto T, Isotani A, Ikawa M, Tachibana T, Okada Y, Kimura H, Ohkawa Y, Kurumizaka H and Yamagata K (2017)
Cell Reports
- Epigenetic modifications and reprogramming in paternal pronucleus: sperm, preimplantation embryo, and beyond.
Okada Y and Yamaguchi K (2017)
Cellular and Molecular Life Sciences
2016
- ARCN1 Mutations Cause a Recognizable Craniofacial Syndrome Due to COPI-Mediated Transport Defects.
Izumi K, Brett M, Nishi E, Drunat S, Tan ES, Fujiki K, Lebon S, Cham B, Masuda K, Arakawa M, Jacquinet A, Yamazumi Y, Chen ST, Verloes A, Okada Y, Katou Y, Nakamura T, Akiyama T, Gressens P, Foo R, Passemard S, Tan EC, El Ghouzzi V and Shirahige K (2016)
American Journal of Human Genetics
2015
2014
2013
2011
2010
- The human polyoma JC virus agnoprotein acts as a viroporin.
Suzuki T, Orba Y, Okada Y, Sunden Y, Kimura T, Tanaka S, Nagashima K, Hall WW and Sawa H (2010)
PLOS Pathogens
- A role for the elongator complex in zygotic paternal genome demethylation.
Okada Y, Yamagata K, Hong K, Wakayama T and Zhang Y (2010)
Nature
- Histone demethylase JHDM2A is involved in male infertility and obesity.
Okada Y, Tateishi K and Zhang Y (2010)
Journal of Andrology
2009
2007
2006
2005
- hDOT1L links histone methylation to leukemogenesis.
Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G and Zhang Y (2005)
Cell
- Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation.
Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, Tanaka S, Fujita T, Kuroda S, Nagashima K and Sawa H (2005)
Journal of Biological Chemistry
- Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role in nuclear egress of viral particles.
Okada Y, Suzuki T, Sunden Y, Orba Y, Kose S, Imamoto N, Takahashi H, Tanaka S, Hall WW, Nagashima K and Sawa H (2005)
EMBO reports
2004
2003
2002
- Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription.
Takai H, Naka K, Okada Y, Watanabe M, Harada N, Saito S, Anderson CW, Appella E, Nakanishi M, Suzuki H, Nagashima K, Sawa H, Ikeda K and Motoyama N (2002)
EMBO Journal
- Differential requirement for Apaf1 and Bcl-X(L) in the regulation of programmed cell death during development.
Yoshida H, Okada Y, Kinoshita N, Hara H, Sasaki M, Sawa H, Nagashima K, Mak TW, Ikeda K and Motoyama N (2002)
Cell Death & Differentiation
- Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
Kobayashi Y, Watanabe M, Okada Y, Sawa H, Takai H, Nakanishi M, Kawase Y, Suzuki H, Nagashima K, Ikeda K and Motoyama N (2002)
Molecular and Cellular Biology
- Expression of JC virus agnoprotein in progressive multifocal leukoencephalopathy brain.
Okada Y, Sawa H, Endo S, Orba Y, Umemura T, Nishihara H, Stan AC, Tanaka S, Takahashi H and Nagashima K (2002)
Acta Neuropathologica
2001
- Distribution and function of JCV agnoprotein.
Okada Y, Endo S, Takahashi H, Sawa H, Umemura T and Nagashima K (2001)
Journal of NeuroVirology
- Interaction of JC virus agno protein with T antigen modulates transcription and replication of the viral genome in glial cells.
Safak M, Barrucco R, Darbinyan A, Okada Y, Nagashima K and Khalili K (2001)
Journal of Virology
- Broad distribution of the JC virus receptor contrasts with a marked cellular restriction of virus replication.
Suzuki S, Sawa H, Komagome R, Orba Y, Yamada M, Okada Y, Ishida Y, Nishihara H, Tanaka S and Nagashima K (2001)
Virology
- Distribution of rabbit haemorrhagic disease virus RNA in experimentally infected rabbits.
Kimura T, Mitsui I, Okada Y, Furuya T, Ochiai K, Umemura T and Itakura C (2001)
Journal of Comparative Pathology
2000
- CalDAG-GEFIII activation of Ras, R-ras, and Rap1.
Yamashita S, Mochizuki N, Ohba Y, Tobiume M, Okada Y, Sawa H, Nagashima K and Matsuda M (2000)
Journal of Biological Chemistry
- Transcriptional activation of JC virus by human T-lymphotropic virus type I Tax protein in human neuronal cell lines.
Okada Y, Sawa H, Tanaka S, Takada A, Suzuki S, Hasegawa H, Umemura T, Fujisawa J, Tanaka Y, Hall WW and Nagashima K (2000)
Journal of Biological Chemistry
日本語著書
- 野老美紀子、山縣一夫、岡田由紀 (2018)
「哺乳類の精子形成から受精卵へ」実験医学増刊号「染色体を解く」（平野達也、胡桃坂仁志 編)、羊土社
- 浦聖恵、岡田由紀 (2017)
「ヒストンバリアント」「遺伝子発現制御機構～クロマチン、転写制御、エピジェネティクス～」（田村隆明・浦聖恵 編著)、東京化学同人
- 羽田政司、岡田由紀. (2014)
「ヒストン制御とエピジェネティクス」、生体の科学 第65巻第6号
- 青島圭佑、岡田由紀. (2013)
「マウス受精卵前核期におけるクロマチンダイナミクス」、生化学誌 第85巻 第4号、公益社団法人日本生化学会
- 牧野吉倫、岡田由紀. (2012)
「精子形成のエピジェネティック制御機構」、実験医学30 (18)、羊土社
- 岡田由紀、Yi Zhang. (2008)
「精子形成におけるヒストン脱メチル化酵素Jhdm2aの役割」、実験医学26(9) 羊土社
- 岡田由紀、Yi Zhang. (2006)
「ヒストンメチル化と白血病発症」、血液フロンティア、16(1), 医薬ジャーナル社
